With
the development of industry, atopic dermatitis (AD) has becoming more
and more prevalent in the pediatric population, with rates reportedly as
high as 10̄20% in the England[1], and the 0.7% in the population from 6
to 20 years old in China[2]. Modern medicine treatment for this disease
includes corticosteroids, moisturizers, emollients, antihistamines,
antibiotics, immunomodulators, immunosuppressants and etc[3]. Recently,
Complementary and Alternative Medicine, Includes Traditional Chinese
medicine, has started to become a new research focus, and these studies
mainly focused on reducing the amount of the use of corticosteroids and
reducing the side effects of corticosteroids in patients of AD. Chinese
medicine treatment of atopic dermatitis has a long history. However, so
far, most of the Chinese medicine researches of atopic dermatitis focus
on the summary of the doctor̉s experience. Code Shoppy
The use of modern data mining methods to explore the topical treatment
Recipes about atopic dermatitis of Traditional Chinese medicine topical
herbs study have not yet to see. The aim of the study is to use the
unsupervised data mining methods to analyze Traditional Chinese medicine
topical herbs for treating atopic dermatitis, so as to provide
references for clinical treatment of AD.
A.Source
of Recipes A computer-based online search of relevant Chinese articles
in the China Medical Code(Zhong-Hua-Yi-Dian), which is a datebase that
concluded the Chinese ancient literature. The keywords of search term
con-luded “Four bend wind(Si-Wan-Feng)”, “Milk ringworm(Nai-xuan)”,
“Fetal sores(Tai-Lian-Chuang)”, “eyebrow sores(Lian-Mei-Chuang)” ,“Fetal
ringworm(Tai-xuan)”, “Steeped sores(Jin-Yin-Chuang)”, “Blood winds
sores(Xue-Feng-Chuang)”. B.Screening of Recipes We will exclude the
recipes which contain only one Chinese topical herb, and selects recipes
which contains two or more Chinese topical herbs. What’s more, the
recipes which contain the oral plus topical herbs to treat AD are also
excluded objects, because our aim is to explore the topical herbs on the
impact of AD this time. C.Construction of Database We will take the
Microsoft Net framework 3.5 as the development platform, and the
computer program, all the Chinese herbs names in the recipes will become
bi-value variable. Point-striking the Chinese herbs involved in a
certain recipe by the mouse, that is, their values will be defined as
“1” and the values of other drugs will be automatically expressed as
“0”. From 84 Chinese articles, 84 Chinese drug recipes for the treatment
of this class of diseases will be collected, 138 commonly-used Chinese
drugs and a corresponding database of Chinese medicine topical herbs in
recipes for AD will be constructed. D.Analysis Methods The data will be
analyzed through the modified mutual information methods developed by
this research group, for example, complex system entropy cluster method,
and unsupervised hierarchical clustering method, and realizing
quantitative description of drug correlation coefficient, and extraction
of core combinations, and discovering new recipes[4]. New recipes refer
to those achieved according to the data mining methods, and these dates
are not existed in previous database. For the mining methods, on the
one hand, the core combinations of Chinese herbs for AD will be acquired
by complex system entropy cluster, on the other hand, the core
combinations attained will be deeply mined by unsupervised hierarchical
clustering, which generate new recipes. The principles of the complex
system entropy cluster and the hierarchical clustering are briefly
introduced as follows. xThe complex system entropy cluster.
Online Shopping E-Commerce Android App Project The Determinants of Online Shopping Behavior A.Social Cognitive Theory Reference [7] argued that social cognitive theory is a powerful theory for explaining human behavior. The core argument of social cognitive theory is that cognitive personal and environmental factors affect behavior [7, 16]. Reference [7] indicated that the primary statement in social cognitive theory is that there is a triadic mechanism among personal characteristics, such as cognitive states, psychical features, such as external environment factors, and behavior. Reference [7] shown that an individual’s perception can mold behavior. The way people think and feel is related to behavior. In other words, the cognitive state may influence individual’s behavior. Reference [7] expressed that the environment which individuals surround within is related to behavior. The environment which involves in social cognitive theory includes physical environment a
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